Haemolytic uraemic syndrome is a form of thrombotic microangiopathy affecting predominantly the kidney and characterised by a triad of thrombocytopenia, mechanical haemolytic anaemia, and acute kidney injury. The term encompasses several disorders: shiga toxin-induced and pneumococcus-induced haemolytic uraemic syndrome, haemolytic uraemic syndrome associated with complement dysregulation or. Haemolytic uraemic syndrome (HUS) is a rare condition, which can be caused by infection with a bacteria that releases toxins into the body. Toxic strains of E.coli bacteria, such as E.coli 0157, belong to a group of enterohaemorrhagic E.coli (EHEC), which cause haemorrhagic colitis (bloody diarrhoea). About 10 per cent of patients with EHEC develop HUS The hemolytic-uremic syndrome. Nephron. 1973; 11 (2):174-192. Vitacco M, Sanchez Avalos J, Gianantonio CA. Heparin therapy in the hemolytic-uremic syndrome. J Pediatr. 1973 Aug; 83 (2):271-275. Upadhyaya K, Barwick K, Fishaut M, Kashgarian M, Siegel NJ. The importance of nonrenal involvement in hemolytic-uremic syndrome. Pediatrics Hemolytic Uremic Syndrome (HUS) Lucy Liu 0 % Topic. Review Topic. 0. 0. N/A. N/A. Questions. 3 3. 0. 0. 0 % 0 % Evidence. 2 2. 0. 0. Snapshot: A 7-year-old boy recently had several episodes of bloody diarrhea. Desperate, his parents called his primary care physician, who reassured them that the infection is self-limited
Hemolytiskt uremiskt syndrom (HUS) är en sjukdom som kännetecknas av de tre komponenterna: . Akut njursvikt ()Mikroangiopatisk hemolytisk anemi; Trombocytopeni (lågt antal trombocyter, blödningsbenägenhet); Hemolytiskt uremiskt syndrom beror vanligen på en infektion av enterohemorragiska E. coli (EHEC, vanligtvis serotypen O157:H7).EHEC utsöndrar ett verotoxin som är toxiskt för. Streptococcus pneumonia-associated hemolytic uremic syndrome (HUS) (pneumococcal HUS) is an uncommon condition mainly observed in young children. Early recognition is critical, because of the potential to improve morbidity and mortality. In our review we summarize the pathophysiology, clinical features, diagnostic difficulties and management of this potentially under-diagnosed condition Overview Definition. Hemolytic uremic syndrome (HUS) is a disease of the capillaries (microangiopathy) that causes the formation of blood clots, anemia caused by the destruction of RBC in these clotted capillaries (hemolytic anemia), acute kidney injury, and low platelets (thrombocytopenia).Epidemiology. Majority of cases seen in children < 5 years of ag Doctors suspect hemolytic-uremic syndrome (HUS) when they find a low platelet count in children who have been ill or, less commonly, in those who have taken certain drugs. Although there are no blood tests that specifically diagnose HUS, doctors do a number of blood tests that, together with people's symptoms, help make the diagnosis
Hemolytic uremic syndrome (HUS) is a condition that affects the blood and blood vessels. It results in the destruction of blood platelets (cells involved in clotting), a low red blood cell count (anemia) and kidney failure due to damage to the very small blood vessels of the kidneys. Other organs, such as the brain or heart, may also be affected by damage to very small bloo Hemolytic uremic syndrome was first described in 1955, but it was not known to be secondary to Escherichia coli (E. coli) infections until 1983.HUS is now recognized as a cause of acute kidney failure in infants and young children Hemolytic uremic syndrome (HUS) is a serious renal disease, and the most common etiologic factor in the development of acute renal failure in children. Most affected children are younger than 4. Hemolytic uremic syndrome (HUS) is characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Most cases of HUS occur in children and are diarrhea-associated (D+ HUS). Diarrhea-associated HUS is usually caused by Shiga toxin-producing . Rarely oth.. . Dom misstänker att hon har fått något som kallas för hemolytic uremic syndrome. Alla symtomen hon har stämmer bra in på det. Det är ju lite läskiga symtom på den här, så lite nervös är man ju. Någon som har haft det här
Hemolytic uremic syndrome (HUS) is a condition in which there is destruction of red blood cells (), low platelet count, and kidney failure.In hemolytic uremic syndrome, blood within the small blood vessels known as capillaries begins to clot abnormally. When red blood cells pass through the clogged capillaries, they are sheared apart and broken 1. Bernarda Viteri, MD* 2. Jeffrey M. Saland, MD† 1. *Children's Hospital of Philadelphia, Philadelphia, PA 2. †Mount Sinai Kravis Children's Hospital, New York, NY Thrombotic microangiopathy (TMA) was described by Moschcowitz in 1924, and the term hemolytic uremic syndrome (HUS) appeared by 1955 to describe a series of patients with small-vessel renal thrombi, thrombocytopenia, and. Hemolytic uremic syndrome (HUS) is a condition that affects the blood and blood vessels. It results in the destruction of blood platelets (cells involved in clotting), a low red blood cell count (anemia) and kidney failure due to damage to the very small blood vessels of the kidneys INTRODUCTION. The hemolytic uremic syndrome (HUS) is defined by the simultaneous occurrence of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury .It is one of the main causes of acute kidney injury in children
Hemolytic uremic syndrome affects males and females in equal numbers. Some studies have suggested that the disorder affects females more severely than males. Hemolytic uremic syndrome can affect children or adults, but is more common in children under 10, especially children between 7 months and 6 years of age . coli O157:H7 infections (mostly young children) goes on to develop Hemolytic Uremic Syndrome, a severe, potentially life-threatening complication. HUS is an extremely complex process that researchers are still trying to fully explain Hemolytic uremic syndrome is a general term that covers five main subtypes STEC (typical), atypical hemolytic uremic syndrome [complement dysregulation], Sp HUS (Streptococcal pneumonia associated HUS) and metabolic causes of HUS. This report covers STEC (typical) hemolytic uremic syndrome,. Hemolytic uremic syndrome affects both children and adults who developed an infection of their digestive system by a specific strain of Escherichia coli (E. coli, O157:H7) that produces a chemical called shiga toxin or less commonly a strain of shigella called Shigella dysenteriae type 1
Hemolytic uremic syndrome as a Cause of Symptoms or Medical Conditions. When considering symptoms of Hemolytic uremic syndrome, it is also important to consider Hemolytic uremic syndrome as a possible cause of other medical conditions. The Disease Database lists the following medical conditions that Hemolytic uremic syndrome may cause Hemolytic uremic syndrome (HUS) is a condition involving red blood cells and your kidneys. HUS happens after you get an infection in your digestive system. The infection makes toxins that destroy red blood cells. These damaged cells block the kidneys' filtering system and can cause your kidneys to fail Prognosis for Hemolytic uremic syndrome: Ninety percent of children with HUS who receive careful supportive care survive past the initial harrowing stages of the condition, and most of those will have no long-term effects. But between 10 percent and 30 percent of the survivors will have kidney damage that leads to permanent kidney failure either immediately or over the course of several years .A seven-month.
Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA)-related disease that manifests as a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI) and is caused by uncontrolled activation of the complement system. We report the case of a 61-year-old woman with acute type A aortic dissection that subsequently developed into aHUS The hemolytic uremic syndrome (HUS) is a rare disease of microangiopathic hemolytic anemia, low platelet count and renal impairment. HUS usually occurs in young children after hemorrhagic colitis. Hemolytic-Uremic Syndrome James J. Corrigan, Jr, MD,* and Frank G. Boineau, MD† Objectives After completing this article, readers should be able to: 1. Describe the laboratory ﬁndings in hemolytic-uremic syndrome (HUS). 2. Delineate the signs and symptoms of HUS. 3. Characterize the association between verotoxin-secreting Escherichia. Hemolytic Uremic Syndrome (HUS) In some persons, particularly children under 5 years of age and the elderly, a shiga toxin-producing E. coli infection can also cause a severe complication called hemolytic uremic syndrome (HUS).. About 2%-7% of E. coli O157:H7 infections lead to HUS.; With HUS Infection, the red blood cells are destroyed and the kidneys fail
Hemolytic uremic syndrome (HUS) is a rare condition that can lead to kidney failure. The syndrome harms the small structures and vessels inside the kidneys. HUS causes red blood cells to clog the tiny blood vessels in the kidneys. It may cause damage to the kidney tissues Atypical hemolytic-uremic syndrome (aHUS) is a life-threatening disease that in most cases progresses to end-stage kidney disease. 1 Rare pathogenic mutations in complement components or regulatory proteins play a crucial role in the pathogenesis of aHUS in 50% to 60% of patients. 2-4 These rare variants cause defective regulation of the complement alternative pathway in the endothelial cell. Patients with hemolytic-uremic syndrome (HUS) have vascular lesions indistinguishable from those observed in patients with TTP, but the renal vasculature endures the most lesions, with minimal. Hemolytic-uremic syndrome (HUS) is a clinical syndrome characterized by progressive renal failure that is associated with microangiopathic (nonimmune, Coombs-negative) hemolytic anemia and.
The hemolytic-uremic syndrome, which is characterized by nonimmune hemolytic anemia, thrombocytopenia, and renal impairment, occurs most frequently in young children. Most cases are secondary to. Hemolytic uremic syndrome definition is - a rare disease that is marked by the formation of thrombi in the capillaries and arterioles especially of the kidney, that is characterized clinically by hemolytic anemia, thrombocytopenia, and progressive kidney failure, that has several causes (such as infection with E. coli or the use of chemotherapeutic or immunosuppressant drugs), and that.
Chapter 1 Hemolytic Uremic Syndrome (HUS) What is the Hemolytic Uremic Syndrome and What Do I Need to Know about It? Hemolytic uremic syndrome was first described in 1955, but it was not known to be secondary to Escherichia coli (E. coli) infections until 1983.HUS is now recognized as a cause of acute kidney failure in infants and young children Hemolytic-uremic syndrome (HUS) is a clinical syndrome characterized by the triad of thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and acute renal failure Hemolytic uremic syndrome or HUS is a rare condition that mainly affects children under the age of 10. It often causes: Most cases of HUS occur after an infection in the digestive tract caused by the E. coli bacterium, O157:H7. Diarrhea and upper respiratory infections are the most common factors.
Atypical hemolytic uremic syndrome (aHUS) is a rare renal disease (two per one million in the USA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Both sporadic (80% of cases) and familial (20% of cases) forms are recognized. The study of familial aHUS has implicated genetic variation in multiple genes in the complement system in disease. Hemolytic-uremic syndrome is a disease characterized by hemolytic anemia, acute kidney failure (uremia), and thrombocytopenia. It predominantly, but not exclusively, affects children, and is the most common cause of acquired acute renal failure in childhood Uremia is the condition of having high levels of urea in the blood. Urea is one of the primary components of urine. It can be defined as an excess of amino acid and protein metabolism end products, such as urea and creatinine, in the blood that would be normally excreted in the urine. Uremic syndrome can be defined as the terminal clinical manifestation of kidney failure (also called renal. Hepatorenalt syndrom (HRS) är ett mycket allvarligt tillstånd som kan uppstå hos personer med allvarlig leversjukdom. De flesta har kronisk leversjukdom (skrumplever), till exempel på grund av infektion (hepatit B eller C) eller alkoholskada. Ibland kan hepatorenalt syndrom även uppstå hos personer med akut leversvikt
Hemolytic-uremic syndromes (HUS) are clinical conditions characterized by acute kidney injury, thrombocytopenia, and microangiopathic hemolytic anemia with evidence of intravascular red blood cell (RBC) destruction demonstrated by fragmented cells (schistocytes) on blood smear Hemolytic uremic (say: HEE-moh-LIT-ick you-REE-mick) syndrome, also called HUS, is a disease of the kidneys, blood, and gastrointestinal system. It is rare in the United States. Who gets HUS Hemolytic uremic syndrome (HUS) usually occurs in children following an episode of diarrheal infection caused by STEC strain O157:H7, and occasionally following infection with Shigella. A number sign (#) is used with this entry because susceptibility to the development of atypical hemolytic uremic syndrome-1 (AHUS1) can be conferred by variation in the gene encoding complement factor H (CFH; 134370) on chromosome 1q31. Deficiency of the CFH-related proteins CFHR1 and CFHR3 may be associated with development of the disorder due to autoantibodies
Sensorimotor neuropathy was a recognized component of the uremic syndrome decades ago. 15 Studies of conduction velocity and other nerve functions have since repeatedly found that the majority of patients with uremia have peripheral neuropathy, albeit often subclinical.16, 29, 30 Morphologic studies have shown that these functional changes are associated with axonal loss. 30 The extent to. Hemolytic Uremic Syndrome: An Emerging Health Risk SAMIYA RAZZAQ, M.D., University of Arkansas for Medical Sciences College of Medicine, Little Rock, Arkansas H emolytic uremic syndrome is th The symptom complex that constitutes the uremic syndrome has long been recognized. Its earliest, most eloquent and succinct description probably was given by Aretaeus of Cappadocia in his The Causes and Indications of Acute and Chronic Diseases sometime during the first century of our era. 1 In Chapter III , titled On the Affections about the Kidneys, he states
Sensorimotor neuropathy was a recognized component of the uremic syndrome decades ago. 14 Studies of conduction velocity and other nerve functions have since repeatedly found that the majority of patients with uremia have peripheral neuropathy, albeit often at a subclinical level.15., 28., 29 Find people with Hemolytic-uremic Syndrome through the map. Connect with them and share experiences. Join the Hemolytic-uremic Syndrome community. View map. Stories of Hemolytic-uremic Syndrome. HEMOLYTIC-UREMIC SYNDROME STORIES. VIEWS. BY. TAYLYNN. TayLynn was 3 years old when she contacted E-coli from an unknown source
Hemolytic uremic syndrome is a multisystem disorder that is triggered by bacterial gastroenteritis with Shiga toxin-producing enterohemorrhagic Escherichia coli.Typically HUS sporadically affects children younger than 3 years of age and is characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. 1 Even though central nervous system involvement is a known. Hemolytic uremic syndrome is the most frequent cause of acute renal failure in children. The disease is characterised by a specific clinical picture and by particular laboratory results Pathophysiology of Hemolytic-Uremic Syndrome. The most important pathogenic step in the pathophysiology of HUS is the formation of microthrombi within the arterioles and capillaries.This is the result of endothelial cell injury.When red blood cells become entrapped within these microscopic thrombi, they are fragmented and hemolysis ensues.. The most common cause of HUS is O157:H7 E. coli.
820 Jorie Blvd., Suite 200 Oak Brook, IL 60523-2251 U.S. & Canada: 1-877-776-2636 Outside U.S. & Canada: 1-630-571-787 This syndrome is most commonly associated with infections caused by shiga toxin-producing Eschericha coli (STEC), but may also result from infections caused by Salmonella and Shigella, other types of infections, and sometimes from non-infectious causes
. Among children, the most common cause of HUS is infection with a Shiga toxin-producing organism, most commonly . Escherichia coli . O157:H7 or some other strain of Shiga toxin-producing Hemolytic Uremic Syndrome (HUS) หรือกลุ่มอาการฮีโมไลติกยูรีมิก เป็นความผิดปกติที่เกิดขึ้นเมื่อหลอดเลือดขนาดเล็กในไตได้รับความเสียหายหรือเกิดการอักเสบจนอาจ.
Atypical Hemolytic Uremic Syndrome (aHUS) is a rare chronic disease, different from typical hemolytic uremic syndrome (HUS). Typical HUS is caused by bacteria, specifically E. Coli (Hemolytic uremic syndrome (HUS), 2016; Noris & Remuzzi, 2010). It can be treated, and most children will have a. Along with a report of the first outbreak of hemolytic uremic syndrome (HUS) caused by Shiga-like toxin (SLT) producing E. coli in Australia , this issue of Emerging Infectious Diseases presents three papers detailing the investigations of pediatric HUS cases linked to Shiga toxin (ST) and SLT producing bacteria. Goldwater and Bettelheim present a case of pediatric HUS associated with SLT. Hemolytic uremic syndrome is a rare medical condition which can cause severe kidney failure, anemia, and dangerously high blood pressure.The condition is almost always the result of consuming foods that contain a particular strain of the Escherichia coli (E. coli) bacteria.Hemolytic uremic syndrome primarily affects children under the age of 15, whose immune systems have not yet fully. Answer: Hemolytic Uremic Syndrome (HUS) 1-4 Definition: A microangiopathic hemolytic anemia +/- thrombocytopenia and renal insufficiency/failure. Renal insufficiency/failure => damage to renal vascular endothelium => deposition of platelets, complement, and fibrin => thrombocytopenia and reduced glomerular filtration rate
Atypical hemolytic uremic syndrome (aHUS) is an extremely rare disease characterized by low levels of circulating red blood cells due to their destruction (hemolytic anemia), low platelet count (thrombocytopenia) due to their consumption and inability of the kidneys to process waste products from the blood and excrete them into the urine (acute kidney failure), a condition known as uremia Hemolytic-uremic syndrome (HUS) is a serious disorder that usually occurs in children and involves the formation of small blood clots throughout the body that block the flow of blood to vital organs such as the brain, heart, and kidneys. The small blood clots that form in HUS block small blood. Hemolytic Uremic Syndrome (HUS) Fact Sheet What is the treatment for HUS? Treatment for HUS is mostly supportive care to relieve symptoms and return body functions to normal. Intravenous (IV) fluids and blood transfusions might be given. Dialysis might be required if the patient develops kidney failure Hemolytic uremic syndrome or HUS is described as a disease of both the circulatory system and the urinary system. Hemolysis simply means obliteration of the red blood cells. In Hemolytic uremic syndrome, the blood inside the capillaries or small blood vessels starts to clot unusually
Fig.2 Platelets and atypical hemolytic uremic syndrome. (Afshar-Kharghan, 2008) Creative Biolabs has established advanced Complement Therapeutics platform including antibody engineering platform, protease inhibitor platform, and drug discovery platform, and is equipped to offer a full range of biotherapeutics development services regarding drug discovery and validation for HUS Care guide for Hemolytic Uremic Syndrome (Inpatient Care). Includes: possible causes, signs and symptoms, standard treatment options and means of care and support Hemolytic uremic syndrome (HUS) Definition. HUS is an illness in which the red blood cells are destroyed and the kidneys fail. HUS is a condition that can follow diarrhea caused by E. coli O157:H7 or Shigella dysenteriae. It can be serious, however, only a small percent of people with E. coli O157:H7 or Shigella dysenteriae develop HUS 235400 - HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1; AHUS1 - Diarrhea-associated (D+HUS), occurs in children younger than 3 years, associated with verotoxin-producing E. coli (90% of patients) (typical HUS) [UMLS: C3550380] - D+HUS (typical HUS) is usually sporadic, limited to 1 event, and has a good prognosis [UMLS: C3550381 The hemolytic uremic syndrome (HUS) is a rare disease of microangiopathic hemolytic anemia, low platelet count and renal impairment. HUS usually occurs in young children after hemorrhagic colitis by shigatoxin-producing enterohemorrhagic E. coli (D+HUS). HUS is the most common cause of acute renal failure in infants and young children, and is a substantial cause of acute mortality and.
Atypical hemolytic uremic syndrome (aHUS) is a very rare disease state that causes thrombi in the small blood vessels, blocking blood flow and resulting in end-organ dysfunction. As a result, patients may experience hemolytic anemia, thrombocytopenia, and acute kidney failure. Since aHUS has a poor. Hemolytic Uremic Syndrome: A Dangerous Complication of E. coli Bill Marler. Hemolytic uremic syndrome Najib Suhrabi. Haemolytic uraemic syndrome anestezjolog. Diabetes update for registrars part 1 - 13 08 14 fracpractice. English Español Português. Hemolytic uremic syndrome patient follow-up. Children who appear to have recovered from HUS may develop late complications. A precise determination of the risk of late complications is not likely. It is important to note that the risks of longer term (more than 20 years).
Atypical hemolytic uremic syndrome (aHUS) primarily affects the kidneys. But it can also damage other organs, including the eyes. Vision problems such as eye pain, blurry vision, and, in severe cases, vision loss have been reported in patients, although they are not considered to be common Behandling av hepatorenalt syndrom. Inj terlipressin (Glypressin) 0,5-2 mg var 4-6 timme initialt under 3 dygn, vid utebliven förbättring av kreatinin med >25 % ökas dosen till 2 mg x 4-6. Ett nyare alternativ är att ge 2 mg per dygn som infusion, Terlipressin 1 mg blandas i så fall med NaCl 250 ml och ges initialt på 12 timmar
Atypical Hemolytic Uremic Syndrome Pipeline Research Monitor 2020 - Drugs, Companies, Clinical Trials, R&D Pipeline Updates, Status and Outlook - ResearchAndMarkets.com July 24, 2020 05:57 AM. Looking for the abbreviation of Hemolytic Uremic Syndrome? Find out what is the most common shorthand of Hemolytic Uremic Syndrome on Abbreviations.com! The Web's largest and most authoritative acronyms and abbreviations resource Hemolytic Uremic Syndrome [HUS] is defined by the almost simultaneous onset of acute renal failure, acute hemolytic anemia with fragmented erythrocytes and thrombocytopenia Access Hemolytic uremic syndrome, post-diarrheal national notifiable time periods and case definitions. Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content. Start of Search Controls. Search Form Controls. TOPIC ONLY. Search The CDC. cancel submit 10. Loirat C, Frémeaux-Bacchi V. Atypical hemolytic uremic syndrome. Orphanet J Rare Dis. 2011;6(1):60-90. 11. Mitra D, Jaffe EA, Weksler B, Hajjar KA, Soderland C, Laurence J. Thrombotic thrombocytopenic purpura and sporadic hemolytic-uremic syndrome plasmas induce apoptosis in restricted lineages of human microvascular endothelial cells
Hemolytic Uremic Syndrome. Hemolytic uremic syndrome is a serious disease that affects the kidneys and the ability to clot blood. In severe cases, the red blood cells are destroyed, resulting in anemia and kidney failure. It is a rare disease that affects children more often than adults . in hemolytic uremic syndrome (HUS): hemolytic anemia and thrombocytopenia, leading to acute renal failure characterized by a sudden onset of gastrointestinal bleeding in children. Incidence 6,047 reported cases of shiga toxin-producing E. Coli (STEC) in 201 Hemolytic-Uremic Syndrome Definition Hemolytic-uremic syndrome (HUS) is a rare condition that affects mostly children under the age of 10, but also may affect the elderly as well as persons with other illnesses. HUS, which most commonly develops after a severe bowel infection with certain toxic strains of a bacteria, is characterized by destruction of. Figure 1. Glomerular pathology in hemolytic uremic syndrome (A) In the normal glomerulus, patent capillary lumina containing erythrocytes stain yellow (arrowhead).(B) In hemolytic uremic syndrome, the glomerular capillary loops contain fibrin thrombi and microthrombi that stain bright red (black arrow). There is endothelial cell swelling with obliteration of some of the capillary lumina. Hemolytic uremic syndrome refers to the symptom triad of hemolytic anemia, thrombocytopenia and renal insufficiency, with most cases being triggered by bacterial pathogens. A minor share of cases is of unknown etiology and are classified as atypical hemolytic uremic syndrome. Atypical Hemolytic Uremic Syndrome (aHUS): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and.
hemolytic uremic syndrome is a topic covered in the Taber's Medical Dictionary.. To view the entire topic, please sign in or purchase a subscription.. Nursing Central is an award-winning, complete mobile solution for nurses and students Hemolytic uremic syndrome (HUS) is a condition that results from the abnormal premature destruction of red blood cells. Once this process begins, the damaged red blood cells start to clog the filtering system in the kidneys, which may eventually cause the life-threatening kidney failure associated with hemolytic uremic syndrome LDH 2784 U/L, S. Haptoglobin was <0.01 g/L and DAT negative. Stool for Shigella toxin was negative. ADAMTS13 level was 78%. Blood film demonstrated fragmented red cells, helmet cells, microspherocytes, polychromasia. A diagnosis of atypical hemolytic uremic syndrome (HUS) secondary to missed miscarriage was made Hemolytic-Uremic Syndrome () Definition (MSHCZE) Onemocnění charakterizované hemolýzou v souvislosti s poškozením cévního povrchu - tzv. trombotickou mikroangiopatií, poklesem počtu krevních destiček (trombocytopenií s možnými krvácivými projevy) a akutním selháním ledvin